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Moroxydine

CAT: 0804-HY-W016937Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W016937Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV) . Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].
CAS Number
3731-59-7
Product Name Alternative
ABOB
UNSPSC
12352005
Hazard Statement
H225
Target
Apoptosis; Caspase; HCV; HSV; Influenza Virus
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Smiles
N=C(NC(N1CCOCC1)=N)N
Molecular Formula
C6H13N5O
Molecular Weight
171.20
Precautions
P210-P243-P273-P403
References & Citations
[1]Yu XB, et al. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul;131:156-65. |[2]Yu XB, et al. In vitro antiviral efficacy of moroxydine hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus. Dis Aquat Organ. 2016 Oct 27;121 (3) :189-199. |[3]Yu XB, et al. Effects of moroxydine hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation. Res Vet Sci. 2018 Apr;117:37-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
Caspase 3

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