Pyruvate carboxylase

• UNSPSC Description:

  Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3− and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells[1][2].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Enzyme

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pyruvate-carboxylase.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [Pyruvate carboxylase]

• References & Citations:

  [1]Jitrapakdee S, et al. Structure, mechanism and regulation of pyruvate carboxylase. Biochem J. 2008 Aug 1;413(3):369-87.|[2]Kiesel VA, et al. Pyruvate carboxylase and cancer progression. Cancer Metab. 2021 Apr 30;9(1):20.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9014-19-1