Olomoucine (Standard)

CAT: 0804-HY-W011428RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W011428RSize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 μM), CDK/p35 kinase (IC50=3 μM) and ERK1/p44 MAP kinase (IC50=25 μM) [1][2]. Olomoucine regulates cell cycle and shows anti-melanin tumor activity[3][4].
CAS Number
[101622-51-9]
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others; Cancer
Smiles
CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12
Molecular Formula
C15H18N6O
Molecular Weight
298.34
References & Citations
[1]Vesely, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. European Journal of Biochemistry 224, 771-786 (1994) .|[2]Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biology of the Cell 83 (2), 105-120 (1995) .|[3]Hajdúch M, et al. Induction of apoptosis and regression of spontaneous dog melanoma following in vivo application of synthetic cyclin-dependent kinase inhibitor olomoucine. Anticancer Drugs. 1997 Nov. 8 (10) :1007-13.|[4]Raynaud FI, et al. Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis. Mol Cancer Ther. 2004 Mar. 3 (3) :353-62.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Related Products

CatalogName
HY-W011428-01Olomoucine
HY-W769051Olomoucine-d3
HY-112450Olomoucine II
HY-112382-01Iso-Olomoucine
HY-B0946R-01Sulfamonomethoxine (Standard)
HY-107486R-01Nosiheptide (Standard)
HY-N0465ROlaquindox (Standard)
HY-119419R-01Pirimicarb (Standard)
HY-154817RMetobromuron (Standard)
HY-W013570R-01Acenaphthylene (Standard)

Alternative Products

CatalogName
C4040-10Olomoucine
sc-222099Olomoucine, Dimethylamino-
sc-201528Iso-olomoucine
sc-478686Olomoucine-d3
256101-01Olomoucine discontinued
sc-202750AOlomoucine II

Popular Products