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Olomoucine II

CAT: 0931-T35696-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T35696-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
500735-47-7
Target
ERK, P-gp, CDK
Related Pathways
Neuroscience, Membrane transporter/Ion channel, Cell Cycle/Checkpoint, MAPK
Purity
0.9994
Bioactivity
Olomoucine II is a potent cyclin-dependent kinase inhibitor with IC50 values of 7.6, 0.1, 19.8, 0.45, and 0.06 μM for CDK1, CDK2, CDK4, CDK7, and CDK9, respectively. Olomoucine II demonstrates high selectivity over numerous other kinases while retaining measurable activity against ERK2 and ABCB1, allowing it to modulate multidrug resistance pathways. Olomoucine II suppresses proliferation across cancer cell lines regardless of p53 status and exhibits synergistic action with daunorubicin in ABCB1-expressing HCT-8 cells.Olomoucine II additionally inhibits replication of HSV-1, HSV-2, vaccinia virus, adenovirus 4, and human CMV, making Olomoucine II an important antiviral and anticancer research tool.
Smiles
C(C)(C)N1C=2C(=C(NCC3=C(O)C=CC=C3)N=C(N[C@H](CC)CO)N2)N=C1
Molecular Formula
C19H26N6O2
Molecular Weight
370.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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