Tributyrin (Standard)

• Description:

  Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1].

• UNSPSC:

  12352211

• Target:

  Apoptosis; Interleukin Related; TNF Receptor

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Field of Research:

  Metabolic Disease; Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCC (OCC (OC (CCC) =O) COC (CCC) =O) =O

• Molecular Formula:

  C15H26O6

• Molecular Weight:

  302.36

• References & Citations:

  [1]T Gaschott, et al. Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. J Nutr. 2001 Jun;131 (6) :1839-43.|[2]Claudia P Schröder, et al. Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Int J Oncol. 2002 Jan;20 (1) :195-200.|[3]T Gaschott, et al. Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. J Nutr. 2001 Jun;131 (6) :1839-43.|[4]Claudia P Schröder, et al. Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Int J Oncol. 2002 Jan;20 (1) :195-200.|[5]Maier S, et al. Tributyrin induces differentiation, growth arrest and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines. Int J Cancer. 2000 Oct 15;88 (2) :245-51.|[6]Sato FT, et al. Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism. Cells. 2020 Sep 1;9 (9) :2007.|[7]Yang N, et al. Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice. PLoS One. 2023 Jul 31;18 (7) :e0289364.|[8]Vinolo MA, et al. Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. Am J Physiol Endocrinol Metab. 2012 Jul 15;303 (2) :E272-82.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• Clinical Information:

  Phase 1

• CAS Number:

  60-01-5