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Tributyrin

CAT: 0804-HY-W011404-01Size: 5 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-W011404-01Size:5 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1].
CAS Number
60-01-5
Product Name Alternative
Glyceryl tributyrate
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Apoptosis; Interleukin Related; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/tributyrin.html
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCC(OCC(OC(CCC)=O)COC(CCC)=O)=O
Molecular Formula
C15H26O6
Molecular Weight
302.36
Precautions
H315, H319, H335
References & Citations
[1]T Gaschott, et al. Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. J Nutr. 2001 Jun;131 (6) :1839-43.|[2]Claudia P Schröder, et al. Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Int J Oncol. 2002 Jan;20 (1) :195-200.|[3]Maier S, et al. Tributyrin induces differentiation, growth arrest and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines. Int J Cancer. 2000 Oct 15;88 (2) :245-51.|[4]Sato FT, et al. Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism. Cells. 2020 Sep 1;9 (9) :2007.|[5]Yang N, et al. Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice. PLoS One. 2023 Jul 31;18 (7) :e0289364.|[6]Vinolo MA, et al. Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. Am J Physiol Endocrinol Metab. 2012 Jul 15;303 (2) :E272-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
IL-1

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