DXR-IN-3

• UNSPSC Description:

  DXR-IN-3 is a DXR inhibitor that specifically targets Toxoplasma gondii. DXR-IN-3 shows in vitro activity against the TgDXR enzyme, with an IC50 value of 0.62 μM and a Ki value of 0.19 μM. DXR-IN-3 can inhibit the proliferation of Toxoplasma, with an IC50 value of 5.46 μM[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/dxr-in-3.html

• Smiles:

  O=C(N(C)O)CSC(P(O)(O)=O)C1=CC(Cl)=C(Cl)C=C1

• Molecular Weight:

  360.15

• References & Citations:

  [1]Mazzone F, et al. 1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors. Biochem J. 2024 Aug 21;481(16):1075-1096.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1465907-72-5