Semax (acetate)

• Description:

  Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10) . Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5].

• UNSPSC:

  12352209

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Amyloid-β

• Type:

  Peptides

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/semax-acetate.html

• Purity:

  99.39

• Solubility:

  DMSO : 150 mg/mL (ultrasonic)

• Smiles:

  CC(O)=O.O=C([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CNC=N2)NC([C@@H](NC([C@H](CCSC)N)=O)CCC(O)=O)=O)=O)N3CCC[C@H]3C(NCC(N4CCC[C@H]4C(O)=O)=O)=O

• Molecular Formula:

  C39H55N9O12S

• Molecular Weight:

  873.97

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Medvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228.|[2]Shadrina MI, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001 Aug 3;308 (2) :115-8.|[3]Grivennikov IA, et al. Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons. Restor Neurol Neurosci. 2008;26 (1) :35-43.|[4]Sciacca MFM, et al. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022 Feb 16;13 (4) :486-496.|[5]Eremin KO, et al. Semax, an ACTH (4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005 Dec;30 (12) :1493-500.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [2828433-33-4]