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Semax

CAT: 0804-HY-P1146-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1146-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10) . Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5].
CAS Number
80714-61-0
UNSPSC
12352209
Hazard Statement
H315, H319, H335
Target
Amyloid-β
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/semax.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CNC=N2)NC([C@@H](NC([C@H](CCSC)N)=O)CCC(O)=O)=O)=O)N3CCC[C@H]3C(NCC(N4CCC[C@H]4C(O)=O)=O)=O
Molecular Formula
C37H51N9O10S
Molecular Weight
813.92
Precautions
H315, H319, H335
References & Citations
[1]Medvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228. |[2]Sciacca MFM, et al. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022 Feb 16;13 (4) :486-496. |[3]Grivennikov IA, et al. Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons. Restor Neurol Neurosci. 2008;26 (1) :35-43. |[4]Shadrina MI, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001 Aug 3;308 (2) :115-8. |[5]Eremin KO, et al. Semax, an ACTH (4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005 Dec;30 (12) :1493-500.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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