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Endothelin (16-21)

CAT: 0804-HY-P5769Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P5769Size:1 Each
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Description
Endothelin (16-21) is a selective ETB receptor agonist (EC50=228 nM in guinea-pig bronchus) . Endothelin (16-21) can induce smooth muscle contraction. Endothelin (16-21) is promising for research of respiratory (e.g., asthma) and cardiovascular (e.g., hypertension) diseases[1][2].
CAS Number
121377-67-1
UNSPSC
12352209
Target
Endothelin Receptor
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
N[C@@H](CC1=CN=CN1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O
Molecular Formula
C39H57N9O9
Molecular Weight
795.92
References & Citations
[1]Maggi CA, et al. The C-terminal hexapeptide, endothelin- (16-21), discriminates between different endothelin receptors. Eur J Pharmacol. 1989 Jul 4;166 (1) :121-2.|[2]Douglas SA, et al. Endothelium-dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16-21) and other endothelin-related peptides in the rat. Br J Pharmacol. 1991 Oct;104 (2) :311-20.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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