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Cyclic peptide P1-1

CAT: 0804-HY-P11264Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11264Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclic peptide P1-1 is a high-potent GPR55 antagonist. Cyclic peptide P1-1 antagonizes GPR55 and suppresses collagen secretion. Cyclic peptide P1-1 reduces ROS production, attenuates ER stress, and inhibits mitochondria-associated Apoptosis. Cyclic peptide P1-1 inhibits the expression of α-SMA and COL1α. Cyclic peptide P1-1 ameliorates CCl4 -induce and MCD-diet-induce acute liver inflammation and fibrosis[1].
UNSPSC
12352209
Target
Apoptosis; Collagen; GPR55; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cytoskeleton; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Metabolic Disease
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N[C@H]2[C@@H](C)CC)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(O)=O)NC2=O)N
Molecular Formula
C40H70N12O13S2
Molecular Weight
991.19
References & Citations
[1]Shi Z, et al. Discovery of Novel Peptide Antagonists Targeting GPR55 for Liver Inflammation and Fibrosis. J Med Chem. 2024 Jul 25;67 (14) :12085-12098.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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