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MD5

CAT: 0804-HY-P11260Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11260Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MD5 is a selective TMPRSS6 mimetic peptide inhibitor with an IC50 for recombinant human TMPRSS6 protein of 22 nM and a Ki of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with Ki of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia) [1].
CAS Number
3051556-89-6
UNSPSC
12352209
Target
Ser/Thr Protease; Thrombin
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C([C@@H](NC([C@@H](NC([C@@H](NC(CCC1=CC=CC=C1)=O)CC2=CSC=N2)=O)C3CCCCC3)=O)CCCNC(N)=N)C4=NC5=C(S4)C=CC=C5
Molecular Formula
C36H44N8O4S2
Molecular Weight
716.92
References & Citations
[1]Desgagné M, et al. Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket. J Med Chem. 2024 Aug 8;67 (15) :12969-12983.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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