UPG-108

• Description:

  UPG-108, a peptide compound, is a non-competitive allosteric modulator of Urotensin II receptors (UTR) . UPG-108 significantly enhances the efficacy of UTR agonists but reduces the potency of UTR agonists. UPG-111 efficiently induces calcium release and does not cause contraction of rat aortic rings without endothelial denudation. UPG-111 can be used to study various diseases related to the angiotensinergic system[1].

• UNSPSC:

  12352209

• Target:

  Urotensin Receptor

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

• Smiles:

  O=C([C@@H](NC([C@H](C(C)(SSC[C@H](NC([C@@H](NC([C@@H](NC1=O)CCCN)=O)CC2=CC=C(C=C2)O)=O)C(N[C@H](C(O)=O)C(C)C)=O)C)NC([C@H](CC(O)=O)NC([C@H]3N(CCC3)C([C@H]([C@H](O)C)NC([C@@H](N)CCC(N)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)N[C@@H]1CC5=CNC6=CC=CC=C56

• Molecular Formula:

  C65H88N14O17S2

• Molecular Weight:

  1401.61

• References & Citations:

  [1]Merlino F, et al. Expanding Structure-Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key Role of the N-Terminal Region for Novel Urotensin II Receptor Modulators. J Med Chem. 2024 Aug 22;67 (16) :13879-13890.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [3090686-88-4]