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HVF18-a3-d

CAT: 0804-HY-P11250Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11250Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects[1].
UNSPSC
12352209
Target
Bacterial; ERK; Interleukin Related; JNK; NO Synthase; p38 MAPK; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)
Related Pathways
Anti-infection; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C(N[C@H](C(C)C)C(N[C@H](CC1=CC=CC=C1)C(N[C@H](CCCNC(N)=N)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CC2=CNC3=CC=CC=C23)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](C(C)C)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CC4=CNC5=CC=CC=C45)C(NCC(N[C@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C111H185N31O18
Molecular Weight
2241.85
References & Citations
[1]Kumar SD, et al. Antibacterial, Antibiofilm, and Anti-inflammatory Effects of a Novel Thrombin-Derived Peptide in Sepsis Models: Insights into Underlying Mechanisms. J Med Chem. 2024 Nov 14;67 (21) :19791-19812.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
IL-6; TLR4

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