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Periplanetasin-4

CAT: 0804-HY-P11114Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11114Size:1 Each
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Description
Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana) . Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis[1][2].
CAS Number
2206807-06-7
UNSPSC
12352209
Target
Apoptosis; Bacterial; Caspase; p38 MAPK; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CS)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N4[C@@H](CCC4)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Molecular Formula
C70H110N20O15S
Molecular Weight
1503.81
References & Citations
[1]Yoon IN, et al. The American cockroach peptide periplanetasin-4 inhibits Clostridium difficile toxin A-induced cell toxicities and inflammatory responses in the mouse gut. J Pept Sci. 2017 Nov;23 (11) :833-839.|[2]Lee H, et al. Periplanetasin-4, a novel antimicrobial peptide from the cockroach, inhibits communications between mitochondria and vacuoles. Biochem J. 2019 Apr 26;476 (8) :1267-1284.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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