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Temporin-SHa

CAT: 0804-HY-P11102Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11102Size:1 Each
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Description
Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin -resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC50 = 5-20 μM), and Trypanosoma cruzi (IC50 = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.)[2][3][4][5].
CAS Number
1065010-73-2
UNSPSC
12352209
Target
Bacterial; Fungal; HIV; Parasite
Related Pathways
Anti-infection
Field of Research
Cancer; Infection
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)N
Molecular Formula
C67H109N15O14S
Molecular Weight
1380.74
References & Citations
[1]Lombana A, et al. Temporin-SHa peptides grafted on gold surfaces display antibacterial activity. J Pept Sci. 2014 Jul;20 (7) :563-9. |[2]Dias LM, et al. Antibiofilm Activity and Biocompatibility of Temporin-SHa: A Promising Antimicrobial Peptide for Control of Fluconazole-Resistant Candida albicans. Microorganisms. 2024 Jan 4;12 (1) :99.|[3]Roy M, et al. Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1. Viruses. 2019 Jan 18;11 (1) :77. |[4]Raja Z, et al. Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent. PLoS One. 2017 Mar 20;12 (3) :e0174024.|[5]Shaheen F, et aI. Synthesis of breast cancer targeting conjugate of temporin-SHa analog and its effect on pro- and anti-apoptotic protein expression in MCF-7 cells. Peptides. 2018 Aug;106:68-82.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
HIV-1

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