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PlCSA-BP

CAT: 0804-HY-P11101Size: 1 EachDry Ice: NoHazardous: No
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Description
PlCSA-BP is a Placental CSA-binding peptide. plCSA-BP binds specifically to trophoblasts and not to other cell types in the placenta or to CSA-expressing cells in other tissues. plCSA-BP can guide nanoparticles for the targeted delivery of payloads (such as Indocyanine green (ICG) and Methotrexate (MTX) (HY-14519) ) to the placenta, promising for placenta-specific drug delivery[1].
CAS Number
2294870-89-4
UNSPSC
12352209
Target
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Smiles
O=C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(NCC(N[C@@H](CS)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
Molecular Formula
C142H221N35O44S2
Molecular Weight
3186.61
References & Citations
[1]Zhang B, et al. Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice. Theranostics. 2018 Apr 9; 8 (10) :2765-2781.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Glu-Asp-Val-Lys-Asp-Ile-Asn-Phe-Asp-Thr-Lys-Glu-Lys-Phe-Leu-Ala-Gly-Cys-Leu-Ile-Val-Ser-Phe-His-Glu-Gly-Lys-Cys-OH
CAS Number2294870-89-4
PubChem CID178203514
IUPAC Name(4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2R)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[[(1R)-1-carboxy-2-sulfanylethyl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Molecular FormulaC142H221N35O44S2
Molecular Weight3186.6
XLogP-16.4
Topological Polar Surface Area1290
Hydrogen Bond Donor Count45
Hydrogen Bond Acceptor Count52
Rotatable Bond Count110
Heavy Atom Count223
Formal Charge0
Complexity7170
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)N
InChI
InChI=1S/C142H221N35O44S2/c1-15-75(11)114(175-133(211)98(62-110(191)192)168-123(201)87(43-29-33-53-146)159-137(215)112(73(7)8)173-132(210)97(61-109(189)190)161-118(196)83(147)44-47-106(183)184)139(217)170-96(60-103(148)180)130(208)165-93(57-80-36-22-18-23-37-80)128(206)169-99(63-111(193)194)134(212)177-116(78(14)179)141(219)160-86(42-28-32-52-145)121(199)158-89(46-49-108(187)188)124(202)156-85(41-27-31-51-144)122(200)164-92(56-79-34-20-17-21-35-79)126(204)162-90(54-71(3)4)125(203)153-77(13)117(195)150-65-105(182)155-101(68-222)136(214)163-91(55-72(5)6)131(209)176-115(76(12)16-2)140(218)174-113(74(9)10)138(216)171-100(67-178)135(213)166-94(58-81-38-24-19-25-39-81)127(205)167-95(59-82-64-149-70-152-82)129(207)157-88(45-48-107(185)186)119(197)151-66-104(181)154-84(40-26-30-50-143)120(198)172-102(69-223)142(220)221/h17-25,34-39,64,70-78,83-102,112-116,178-179,222-223H,15-16,26-33,40-63,65-69,143-147H2,1-14H3,(H2,148,180)(H,149,152)(H,150,195)(H,151,197)(H,153,203)(H,154,181)(H,155,182)(H,156,202)(H,157,207)(H,158,199)(H,159,215)(H,160,219)(H,161,196)(H,162,204)(H,163,214)(H,164,200)(H,165,208)(H,166,213)(H,167,205)(H,168,201)(H,169,206)(H,170,217)(H,171,216)(H,172,198)(H,173,210)(H,174,218)(H,175,211)(H,176,209)(H,177,212)(H,183,184)(H,185,186)(H,187,188)(H,189,190)(H,191,192)(H,193,194)(H,220,221)/t75-,76-,77-,78+,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,112-,113-,114-,115-,116-/m0/s1
InChIKey
PQSSTEWRSLCEEX-SGQVLSOFSA-N
Chemical Structure
2D Structure
2D structure of H-Glu-Asp-Val-Lys-Asp-Ile-Asn-Phe-Asp-Thr-Lys-Glu-Lys-Phe-Leu-Ala-Gly-Cys-Leu-Ile-Val-Ser-Phe-His-Glu-Gly-Lys-Cys-OH
CAS: 2294870-89-4
CID: 178203514
Formula: C142H221N35O44S2
MW: 3186.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight3186.6
XLogP3-16.4
Hydrogen Bond Donor Count45
Hydrogen Bond Acceptor Count52
Rotatable Bond Count110
Exact Mass3185.5606626
Monoisotopic Mass3184.5573078
Topological Polar Surface Area1290 Ų
Heavy Atom Count223
Formal Charge0
Complexity7170
Isotope Atom Count0
Defined Atom Stereocenter Count29
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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