LS10

CAT: 0804-HY-P10983Size: 1 EachDry Ice: NoHazardous: No

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Description

LS10 can specifically bind to NG2 protein and is a functional ligand for targeted drug delivery to glioma. NG2 proteins are widely overexpressed in the glioma cells and restricted in normal tissue[1].

CAS Number

241478-24-0

UNSPSC

12352209

Target

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Cancer

Smiles

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

Molecular Formula

C54H90N14O13S

Molecular Weight

1175.44

References & Citations

[1]Chi Y, et al. Glioma homing peptide-modified PEG-PCL nanoparticles for enhanced anti-glioma therapy. J Drug Target. 2016;24 (3) :224-32.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Chemical Information

H-Leu-Thr-Leu-Arg-Trp-Val-Gly-Leu-Met-Ser-OH

CAS Number	241478-24-0
PubChem CID	9876886
IUPAC Name	(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxypropanoic acid
Molecular Formula	C54H90N14O13S
Molecular Weight	1175.4
XLogP	-1.4
Topological Polar Surface Area	471
Hydrogen Bond Donor Count	16
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	37
Heavy Atom Count	82
Formal Charge	0
Complexity	2150

SMILES

C[C@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC(C)C)N)O

InChI

InChI=1S/C54H90N14O13S/c1-27(2)20-34(55)45(72)68-44(31(9)70)52(79)65-39(22-29(5)6)49(76)62-36(16-13-18-58-54(56)57)46(73)64-40(23-32-24-59-35-15-12-11-14-33(32)35)50(77)67-43(30(7)8)51(78)60-25-42(71)61-38(21-28(3)4)48(75)63-37(17-19-82-10)47(74)66-41(26-69)53(80)81/h11-12,14-15,24,27-31,34,36-41,43-44,59,69-70H,13,16-23,25-26,55H2,1-10H3,(H,60,78)(H,61,71)(H,62,76)(H,63,75)(H,64,73)(H,65,79)(H,66,74)(H,67,77)(H,68,72)(H,80,81)(H4,56,57,58)/t31-,34+,36+,37+,38+,39+,40+,41+,43+,44+/m1/s1

InChIKey

JHULOAYQYPMHGD-JMLDBKNKSA-N

Chemical Structure

2D Structure

CAS: 241478-24-0

CID: 9876886

Formula: C54H90N14O13S

MW: 1175.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	1175.4
XLogP3	-1.4
Hydrogen Bond Donor Count	16
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	37
Exact Mass	1174.65325015
Monoisotopic Mass	1174.65325015
Topological Polar Surface Area	471 Å²
Heavy Atom Count	82
Formal Charge	0
Complexity	2150
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
TP3712-01	LS10

LS10

Chemical Information

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