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RI-OR2-TAT

CAT: 0804-HY-P10824Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10824Size:1 Each
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Description
RI-OR2-TAT is a brain-penetrant inhibitor of β-Amyloid oligomerization, which is produced by adding the HIV protein transduction domain TAT to RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a Kd value of 58-125 nM. RI-OR2-TAT reduces Aβ aggregation and plaque levels, reduces activation of microglia and oxidative damage, and increases the number of young neurons in the dentate gyrus[1].
CAS Number
1430219-69-4
UNSPSC
12352209
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NCC(N[C@H](CC1=CC=CC=C1)C(N[C@H](CC2=CC=CC=C2)C(N[C@H](C(C)C)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(NCC(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(NCC(N[C@H](CC3=CC=C(C=C3)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CCCNC(N)=N)NC(C)=O
Molecular Formula
C117H201N49O23
Molecular Weight
2662.16
References & Citations
[1]Doig AJ, et al. Inhibition of protein aggregation and amyloid formation by small molecules. Curr Opin Struct Biol. 2015 Feb;30:50-56.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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