RI-OR2-TAT

• Description :

  RI-OR2-TAT is a brain-penetrant inhibitor of β-Amyloid oligomerization, which is produced by adding the HIV protein transduction domain TAT to RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a Kd value of 58-125 nM. RI-OR2-TAT reduces Aβ aggregation and plaque levels, reduces activation of microglia and oxidative damage, and increases the number of young neurons in the dentate gyrus[1].

• CAS Number :

  [1430219-69-4]

• UNSPSC :

  12352209

• Target :

  Amyloid-β

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(NCC(N[C@H](CC1=CC=CC=C1)C(N[C@H](CC2=CC=CC=C2)C(N[C@H](C(C)C)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(NCC(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(NCC(N[C@H](CC3=CC=C(C=C3)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CCCNC(N)=N)NC(C)=O

• Molecular Formula :

  C117H201N49O23

• Molecular Weight :

  2662.16

• References & Citations :

  [1]Doig AJ, et al. Inhibition of protein aggregation and amyloid formation by small molecules. Curr Opin Struct Biol. 2015 Feb;30:50-56.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported