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LinTT1 peptide

CAT: 0804-HY-P10786Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10786Size:1 Each
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Description
LinTT1 peptide is a tumor-penetrating peptide with the amino acid sequence AKRGARST. LinTT1 peptide targets peritoneal carcinoma (PC) by binding to the p32 (gC1qR) receptor. It can conjugate with iron oxide nanoworms (NWs) to form a nanocarrier. This nanocarrier is taken up by peritoneal carcinoma cells in vitro and enters the mitochondria; it also exhibits significant tumor targeting and penetration effects in mice. Moreover, LinTT1-functionalized nanocarriers, combined with the pro-apoptotic peptide [D (KLAKLAK) 2], show significant tumor suppression in a mouse peritoneal tumor model. LinTT1 peptide holds promise as a delivery carrier for peritoneal cancer research[1].
CAS Number
2031154-77-3
UNSPSC
12352209
Target
Transmembrane Glycoprotein
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NCCCC[C@H](NC([C@@H](N)C)=O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C36H68N16O12
Molecular Weight
917.03
References & Citations
[1]Hunt H, et al. Targeting of p32 in peritoneal carcinomatosis with intraperitoneal linTT1 peptide-guided pro-apoptotic nanoparticles. J Control Release. 2017 Aug 28;260:142-153.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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