Iturin A-2

• Description:

  Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogenic fungus P. expansum (MIC = 8 µg/disk) . Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells, as well as HeLa cervical cancer cells, with IC50 values of 66.81, 95.04, and 77.5 µg/mL, respectively. In greenhouse studies, Iturin A-2 at concentrations of 100 and 300 mg/kg Iturin A-2 reduces the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg Iturin A-2 reduce the incidence of the disease. Iturin A-2 (12.5 µg/mL) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs[1][2][3][4].

• UNSPSC:

  12352209

• Target:

  Antibiotic; Bacterial

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  O=C1N2[C@](CCC2)([H])C(N[C@@H](C(N[C@H](C(N[C@@H](CC(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@H]1CCC(N)=O)=O)CC(N)=O)=O)CC3=CC=C(C=C3)O)=O)CC(N)=O)=O)CCCCCCCCCCC)=O)CO)=O)CC(N)=O)=O

• Molecular Formula:

  C48H74N12O14

• Molecular Weight:

  1043.17

• References & Citations:

  [1]Bland J M. The first synthesis of a member of the iturin family, the antifungal cyclic lipopeptide, iturin-A2[J]. The Journal of Organic Chemistry, 1996, 61 (16) : 5663-5664.|[2]Jiang J, et al. Production, purification and characterization of ‘Iturin A-2’a lipopeptide with antitumor activity from Chinese Sauerkraut Bacterium Bacillus velezensis T701[J]. International Journal of Peptide Research and Therapeutics, 2021, 27 (3) : 2135-2147.|[3]YE Y, et al. Identification of antifungal substance (Iturin A2) produced by Bacillus subtilis B47 and its effect on southern corn leaf blight[J]. Journal of Integrative Agriculture, 2012, 11 (1) : 90-99.|[4]Miyashiro S, et al. Isolation of iturin A-2 as an inhibitor of cytokinesis of starfish embryos[J]. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1986, 84: 381-384.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [83785-07-3]