Iturin A

• Description :

  Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity[1][2].

• UNSPSC :

  12352209

• Target :

  Apoptosis; Autophagy; Fungal; Reactive Oxygen Species (ROS)

• Type :

  Peptides

• Related Pathways :

  Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/iturin-a.html

• Purity :

  98.53

• Solubility :

  Ethanol : 5 mg/mL (ultrasonic)

• Smiles :

  O=C(N[C@@H](CC(N)=O)C(N[C@H](CC1=CC=C(O)C=C1)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N2CCC[C@H]2C(N[C@H](CC(N)=O)C(N[C@@H](CO)C(N3)=O)=O)=O)=O)=O)=O)=O)C[C@@H]3CCCCCCCC[R]

• References & Citations :

  [1]Gong AD, et al. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS One. 2015 Feb 17;10 (2) :e0116871.|[2]Zhao H, et al. Effects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo. AMB Express. 2021 May 10;11 (1) :67.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [52229-90-0]