RES-701-1

• Description:

  RES-701-1 is a cyclic peptide composed of 16 common L-amino acids, acting as a specific antagonist for the ETB receptor. RES-701-1 can inhibit the binding of 125I-ET-1 (125I-labeled Endothelin (ET) -1) to the ETB receptor, with an IC50 value of 10 nM[1][2].

• UNSPSC:

  12352209

• Target:

  Endothelin Receptor

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  OC (C=C1) =CC=C1C[C@@H] (C (N[C@H] (C (N[C@H] (C (O) =O) CC2=CNC3=CC=CC=C23) =O) CC4=CC=C (C=C4) O) =O) NC ([C@H] (CC (N) =O) NC ([C@H] (CC5=CC=CC=C5) NC ([C@H] (CC6=CC=CC=C6) NC ([C@@H] (NC ([C@H]7NC ([C@@]8 ([H]) N (C ([C@@H] (NC ([C@] (NC (CNC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC (CNC (C7) =O) =O) CC (N) =O) =O) CC9=CNC%10=CC=CC=C9%10) =O) CC%11=CN=CN%11) =O) =O) ([H]) [C@H] (O) C) =O) C) =O) CCC8) =O) =O) CC%12=CNC%13=CC=CC=C%12%13) =O) =O) =O) =O

• Molecular Formula:

  C103H115N23O23

• Molecular Weight:

  2043.16

• References & Citations:

  [1]Tanaka T, et al. RES-701-1, a novel, potent, endothelin type B receptor-selective antagonist of microbial origin. Mol Pharmacol. 1994 Apr;45 (4) :724-30.|[2]Yamasaki M, et al. RES-701-1, a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701 II. Determination of the primary sequence[J]. The Journal of Antibiotics, 1994, 47 (3) : 276-280.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  ETB

• CAS Number:

  151308-34-8