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Tetracosactide

CAT: 0804-HY-P0060-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0060-01Size:1 mg
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Description
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH) . Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC50 of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis[1][3].
CAS Number
16960-16-0
Product Name Alternative
Tetracosactrin; ACTH (1–24)
UNSPSC
12352209
Hazard Statement
H317, H332, H334
Target
CRFR; Melanocortin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.46
Solubility
H2O : ≥ 200 mg/mL
Smiles
O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(NCC(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N7[C@@H](CCC7)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC8=CC=C(C=C8)O)C(N9[C@@H](CCC9)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N
Molecular Formula
C136H210N40O31S
Molecular Weight
2933.44
Precautions
H317, H332, H334
References & Citations
[1]Francesco Iuliano, et al. Adding Slow Release Tetracosactide Acetate to Eltrombopag Improves Haematological Response in ITP Patients with Platelet-Count Fluctuation. 2018 Nov 29;132 (1) .|[2]Kertmen H, et al., Comparative effects of methylprednisolone and tetracosactide (ACTH1-24) on ischemia/reperfusion injury of the rabbit spinal cord. Arch Med Sci. 2018 Oct;14 (6) :1459-1470.|[3]Haslach EM, et al., Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs) . J Med Chem. 2014 Jun 12;57 (11) :4615-28.|[4]Lindhe O, et al., Irreversible binding and adrenocorticolytic activity of the DDT metabolite 3-methylsulfonyl-DDE examined in tissue-slice culture. Environ Health Perspect. 2001 Feb;109 (2) :105-10.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Launched
Isoform
MC4R

Alternative Products

CatalogName
MBS3612192-01Tetracosactide
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AR-T04670-01Tetracosactide Hexaacetate
AR-T04669-01Tetracosactide-d4
208724Adrenocorticotropic Hormone (ACTH, Tetracosactide)
MBS639096-01POMC (ACTH, Pro-opiomelanocortin, Corticotropin-lipotropin, LPH, MSH, NPP, POC, CLIP, Tetracosactide)
P9025-10BPOMC (ACTH, Pro-opiomelanocortin, Corticotropin-lipotropin, LPH, MSH, NPP, POC, CLIP, Tetracosactide) discontinued
A0758-04DACTH (1-24) Tetracosactide (POMC, Adrenocorticotropin, beta Lipotropin, alpha (beta) Melanocyte Stimulating Hormone, CLIP, Corticotropin-lipotropin precursor, LPH, MSH, NPP, POC, Pro-opiomelanocortin)
303094ACTH (Adrenocorticotropic Hormone, Adrenocorticotropin, Adrenocorticotropin Hormone, Alpha Melanocyte Stimulating Hormone, Alpha-MSH, AlphaMSH, Beta Endorphin, Beta Lipotropin, Beta LPH, Beta Melanocyte Stimulating Hormone, Beta-Endorphin, Beta-MSH, CLIP, Corticotropin, Corticotropin Like Intermediary Peptide, Corticotropin Lipotropin, Corticotropin Lipotropin Precursor, Corticotropin-like Intermediary Peptide, Gamma LPH, Gamma-MSH, Lipotropin Beta, Lipotropin Gamma, Lipotropin, Included, LPH, Melanocyte-stimulating Hormone, Included, Melanotropin Alpha, Melanotropin Beta, Melanotropin Gamma, Melanotropin, Included, Met Enkephalin, Met-enkephalin, MSH, NPP, Opiomelanocortin Prepropeptide, POC, POMC, Pomc-1, Pomc1, Pomc2, Pro ACTH Endorphin, Pro Opiomelanocortin, Pro-opiomelanocortin-alpha, Proopiomelanocortin, Proopiomelanocortin Preproprotein, Tetracosactide)

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