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5,7,3',4'-Tetramethoxyflavone

CAT: 0804-HY-N7030-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7030-01Size:10 mg
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Description
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].
CAS Number
855-97-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Fungal; Parasite
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Concentration
10mM
Purity
99.15
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C1C(OC)=CC(OC)=C3
Molecular Formula
C19H18O6
Molecular Weight
342.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu L, et al. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling in vivo and in vitro. Biochem Biophys Res Commun. 2014 Sep 26;452 (3) :682-8.|[2]Wu L, et al. 5,7,3',4'-Tetramethoxyflavone protects chondrocytes from ER stress-induced apoptosis through regulation of the IRE1α pathway. Connect Tissue Res. 2018 Mar;59 (2) :157-166. |[3]Wei G, et al. Absolute bioavailability, pharmacokinetics and excretion of 5,7,30 ,40 -tetramethoxyflavone
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium

Chemical Information

5,7,3',4'-Tetramethoxyflavone

5,7,3',4'-Tetramethylluteolin has been reported in Boesenbergia rotunda, Citrus japonica, and other organisms with data available.

CAS Number855-97-0
PubChem CID631170
IUPAC Name2-(3,4-dimethoxyphenyl)-5,7-dimethoxychromen-4-one
Molecular FormulaC19H18O6
Molecular Weight342.3
XLogP2.1
Topological Polar Surface Area63.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity504
SMILES
COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C=C3OC)OC)OC
InChI
InChI=1S/C19H18O6/c1-21-12-8-17(24-4)19-13(20)10-15(25-18(19)9-12)11-5-6-14(22-2)16(7-11)23-3/h5-10H,1-4H3
InChIKey
CLXVBVLQKLQNRQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5,7,3',4'-Tetramethoxyflavone
CAS: 855-97-0
CID: 631170
Formula: C19H18O6
MW: 342.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight342.3
XLogP32.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass342.11033829
Monoisotopic Mass342.11033829
Topological Polar Surface Area63.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity504
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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