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Ardeemin

CAT: 0804-HY-N5166Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N5166Size:1 Each
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Description
Ardeemin ((-) -Ardeemin) binds to the P-glycoprotein, preventing anticancer agent from being pumped out of cells. Ardeemin reverses the multidrug resistance phenotype of tumor cells and increases the sensitivity of tumor cells to anticancer agent in mammary carcinoma xenografts[1].
CAS Number
148441-25-2
Product Name Alternative
(-) -Ardeemin
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
C=CC(C)([C@]12[C@](NC3=CC=CC=C32)([H])N4[C@@](C(N5[C@@H](C4=O)C)=NC6=CC=CC=C6C5=O)([H])C1)C
Molecular Formula
C26H26N4O2
Molecular Weight
426.51
References & Citations
[1]Haynes SW, et al., Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. ACS Chem Biol. 2013 Apr 19;8 (4) :741-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19248506-01Ardeemin

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