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Periplogenin (Standard)

CAT: 0804-HY-N2414RSize: 1 EachDry Ice: NoHazardous: No
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Description
Periplogenin (Standard) is the analytical standard of Periplogenin. Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis[1][2][3].
CAS Number
514-39-6
UNSPSC
12352005
Target
Caspase; Interleukin Related; Necroptosis; NOD-like Receptor (NLR) ; Pyroptosis; Reactive Oxygen Species (ROS) ; Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer; Inflammation/Immunology
Smiles
O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C4=CC(OC4)=O)CC2)C)([H])[C@@]5([C@@](O)(C[C@@H](O)CC5)CC3)C
Molecular Formula
C23H34O5
Molecular Weight
390.51
References & Citations
[1]Zhang WJ, et al. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016 Apr 1;105:66-79.|[2]Ma X, et al. Periplogenin inhibits pyroptosis of fibroblastic synoviocytes in rheumatoid arthritis through the NLRP3/Caspase-1/GSDMD signaling pathway. Int Immunopharmacol. 2024 May 30;133:112041.|[3]Zhang X, et al. The natural compound periplogenin suppresses the growth of prostate carcinoma cells by directly targeting ATP1A1. Sci Rep. 2024 Sep 3;14 (1) :20509.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Isoform
Caspase 1; IL-1; NLRP3

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