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Myristinin A

CAT: 0804-HY-N16849Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N16849Size:1 Each
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Description
Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC50 of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC50 of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis[1].
CAS Number
145904-69-4
Product Name Alternative
YM 26567-1
UNSPSC
12352005
Target
COX; Fungal; Prostaglandin Receptor
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology
Smiles
OC1=C([C@H]2C3=CC=C(C=C3O[C@@H](C2)C4=CC=C(O)C=C4)O)C(O)=CC(O)=C1C(CCCCCCCCCCC)=O
Molecular Formula
C33H40O7
Molecular Weight
548.67
References & Citations
[1]Sawadjoon S, et al. Atropisomeric myristinins: selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea. J Org Chem. 2002 Aug 9;67 (16) :5470-5.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2

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