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Cnidilide

CAT: 0804-HY-N16450Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N16450Size:1 Each
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Description
Cnidilide is a natural product of alkylphthalein. Cnidilide can be isolated from the rhizomes of Cnidium officinale. Cnidilide reduces the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2 induced by LPS. Cnidilide can inhibit pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Cnidilide can specifically inhibit the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Cnidilide blocks the signaling pathway by inhibiting the transcriptional activity of AP-1 and NF-κB. can be used for research on inflammation conditions[1].
CAS Number
3674-03-1
UNSPSC
12352005
Target
COX; Interleukin Related; JNK; NF-κB; NO Synthase; p38 MAPK; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CCCC[C@H]1[C@]2([H])[C@](C=CCC2)([H])C(O1)=O
Molecular Formula
C12H18O2
Molecular Weight
194.27
References & Citations
[1]Zhang W, et al. Natural phenolic metabolites from endophytic Aspergillus sp. IFB-YXS with antimicrobial activity. Bioorg Med Chem Lett. 2015 Jul 1;25 (13) :2698-701.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; IL-1; IL-6

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