Products for Research Use Only

Cnidilide

CAT: 0013-GTR19279265-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19279265-01Size:50 mg
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Description
Cnidilide is a natural alkyl phthalide compound that can be isolated from the rhizomes of Cnidium officinale. It reduces the production of NO and PGE2 by inhibiting LPS-induced expression of iNOS and COX-2. Additionally, Cnidilide suppresses the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. It specifically inhibits the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Moreover, Cnidilide blocks signaling pathways by inhibiting the transcriptional activities of AP-1 and NF-κB. This compound is useful in the study of inflammatory diseases.
CAS Number
3674-03-1
Smiles
C (CCC) [C@H]1[C@@]2 ([C@] (C (=O) O1) (C=CCC2) [H]) [H]
Molecular Formula
C12H18O2
Molecular Weight
194.27
Notes
For research use only.

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