Illudin B

• Description :

  Illudin B is a DNA-targeting cytotoxin that forms interstrand DNA crosslinks via covalent binding, disrupting DNA replication and transcription. Illudin B induces cell cycle arrest and apoptosis, showing toxicity against multiple tumor cells (e.g., leukemia, breast, lung cancer) [1].

• UNSPSC :

  12352211

• Target :

  Apoptosis; DNA/RNA Synthesis

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Smiles :

  C[C@]1(C2(CC2)[C@@](O)(C(C3=C1[C@H](C(C)([C@H]3O)C)O)=O)C)O

• Molecular Formula :

  C15H22O5

• Molecular Weight :

  282.33

• References & Citations :

  [1]Burgess ML, et al. Characterization of new illudanes, illudins F, G, and H from the basidiomycete omphalotus nidiformis. J Nat Prod. 1999 Nov;62 (11) :1542-4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [134857-03-7]