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Coccinine

CAT: 0804-HY-N15636Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N15636Size:1 Each
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Description
Coccinine ((-) -Coccinine) is a weak inhibitor of SERT (IC50: 196.3 μM; Ki: 106.8 μM) and P-gp (IC50: 0.96 mM) . Coccinine exhibits significant anti-tumor activity against various cancer cell lines, such as breast cancer (MCF7, Hs578T, MDA-MB-231), colon cancer (HCT-15), and lung cancer (A549) . Coccinine can be used in the research of tumors and neurological diseases[1][2].
CAS Number
485-57-4
Product Name Alternative
(-) -Coccinine
UNSPSC
12352005
Target
P-glycoprotein; Serotonin Transporter
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Smiles
CO[C@@H]1C=C2[C@]3([H])C4=CC(OCO5)=C5C=C4C[N@]([C@@]2([H])C[C@@H]1O)C3
Molecular Formula
C17H19NO4
Molecular Weight
301.34
References & Citations
[1]Masi M, et al. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: Anticancer activity of coccinine and montanine. South African Journal of Botany, 2019, 126: 277-281.|[2]Stafford G I, et al. Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae) . South African Journal of Botany, 2013, 88: 101-106.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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