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Merulidial

CAT: 0804-HY-N15600Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N15600Size:1 Each
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Description
Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum) . Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively [1][2][3].
CAS Number
68053-32-7
Product Name Alternative
(-) -Merulidial
UNSPSC
12352211
Target
Antibiotic; Bacterial; DNA/RNA Synthesis; Fungal
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Smiles
O=C[C@@]12[C@@](C1)([C@H]([C@@]3([H])C(CC(C)(C3)C)=C2C=O)O)C
Molecular Formula
C15H20O3
Molecular Weight
248.32
References & Citations
[1]1. Svensson M, et al. Pyrone and pyridone compounds in the liquid culture of Physisporinus sanguinolentus. Phytochemistry. 2001 Apr; 56 (7) :747-51. |[2]2. Quack W, et al. Antibiotics from Basidiomycetes. V merulidial, a new antibiotic from the Basidiomycete Merulius tremellosus Fr. J Antibiot (Tokyo) . 1978 Aug; 31 (8) :737-41. |[3]3. Anke H, et al. Structure-activity relationships for unsaturated dialdehydes. 3. Mutagenic, antimicrobial, cytotoxic, and phytotoxic activities of merulidial derivatives. J Antibiot (Tokyo) . 1989 May; 42 (5) :738-44.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
GTR19266175-01Merulidial

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