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Pyripyropene B

CAT: 0804-HY-N14614Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N14614Size:1 Each
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Description
Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 117 nM[1].
CAS Number
151519-44-7
UNSPSC
12352005
Target
Acyltransferase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
C[C@@]12[C@]3([H])[C@@]([C@H](C[C@@]1([H])[C@@](C)([C@H](CC2)OC(C)=O)COC(CC)=O)OC(C)=O)(OC4=C(C(OC(C5=CN=CC=C5)=C4)=O)[C@@H]3O)C
Molecular Formula
C32H39NO10
Molecular Weight
597.65
References & Citations
[1]Y K Kim, et al. Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D. J Antibiot (Tokyo) . 1994 Feb;47 (2) :154-62.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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