Bufotalin (Standard)

CAT: 0804-HY-N0878RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N0878RSize:1 Each
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Description
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation[1][2].
CAS Number
[471-95-4]
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
C[C@@]1(CC[C@@]2([H])[C@@]3([H])CC[C@@]4([H])[C@@]2(CC[C@H](O)C4)C)[C@@H](C(C=C5)=COC5=O)[C@@H](OC(C)=O)C[C@@]13O
Molecular Formula
C26H36O6
Molecular Weight
444.56
References & Citations
[1]Zhu YR, et al. Bufotalin-induced apoptosis in osteoblastoma cells is associated with endoplasmic reticulum stress activation. Biochem Biophys Res Commun. 2014 Aug 15;451 (1) :112-8.|[2]Zhang DM, et al. Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. Eur J Pharmacol. 2012 Oct 5;692 (1-3) :19-28.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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CatalogName
ALX-350-282-M005Bufotalin
A12024-5Bufotalin 5mg
A12024-50Bufotalin 50mg
A12024-1Bufotalin 1mg
A12024-10Bufotalin 10mg
A12024-100Bufotalin 100mg
A12024-25Bufotalin 25mg
A12024-500Bufotalin 500mg
A12024-10mM-DBufotalin 10mM * 1mL in DMSO
abx098968-01Standard

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