EGTA (tetrasodium)

• Description:

  EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM) . EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Biochemical Assay Reagents

• Related Pathways:

  Others

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.93

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(O[Na])CN(CC(O[Na])=O)CCOCCOCCN(CC(O[Na])=O)CC(O[Na])=O

• Molecular Formula:

  C14H20N2Na4O10

• Molecular Weight:

  468.28

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267 (5 Pt 1) :C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426.|[2]Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29 (3) :211-213.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [13368-13-3]