EGTA

• UNSPSC Description:

  EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].

• Target Antigen:

  Biochemical Assay Reagents

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Others

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/egta.html

• Purity:

  98.0

• Solubility:

  DMSO : < 1 mg/mL (ultrasonic)|H2O : 4.76 mg/mL (ultrasonic;warming;adjust pH to 9 with 1 M NaOH;heat to 60°C)

• Smiles:

  O=C(O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O

• Molecular Weight:

  380.35

• References & Citations:

  [1]Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426|[2]Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Clinical Information:

  No Development Reported

• CAS Number:

  67-42-5