EGTA

CAT: 0804-HY-D0861-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-D0861-01Size:500 mg
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Description
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM) . EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].
CAS Number
[67-42-5]
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/egta.html
Purity
99.89
Solubility
1 M NaOH : ≥ 100 mg/mL|DMSO : < 1 mg/mL (ultrasonic) |H2O : 4.76 mg/mL (ultrasonic; warming; adjust pH to 9 with 1 M NaOH; heat to 60°C)
Smiles
O=C(O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O
Molecular Formula
C14H24N2O10
Molecular Weight
380.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267 (5 Pt 1) :C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426|[2]Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29 (3) :211-213.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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