Products for Research Use Only
RegisterLogin

Lacidipine-d10

CAT: 0804-HY-B0347S-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0347S-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Lacidipine-d10 is the deuterium labeled Lacidipine. Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker[1][2].
CAS Number
1185245-62-8
UNSPSC
12352005
Target
Apoptosis; Calcium Channel; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
C(OC(C([2H])([2H])[2H])([2H])[2H])(=O)C=1C(C(C(OC(C([2H])([2H])[2H])([2H])[2H])=O)=C(C)NC1C)C2=C(C=CC(OC(C)(C)C)=O)C=CC=C2
Molecular Formula
C26H23D10NO6
Molecular Weight
465.60
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32 (4) : p. 1040-9.|[3]van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12 (3) : p. 183-7.|[4]Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16 (21) : p. 1353-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

Lacidipine-d10
CAS Number1185245-62-8
PubChem CID45039638
IUPAC Namebis(1,1,2,2,2-pentadeuterioethyl) 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
Molecular FormulaC26H33NO6
Molecular Weight465.6
XLogP4.5
Topological Polar Surface Area90.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Heavy Atom Count33
Formal Charge0
Complexity805
SMILES
[2H]C([2H])([2H])C([2H])([2H])OC(=O)C1=C(NC(=C(C1C2=CC=CC=C2/C=C/C(=O)OC(C)(C)C)C(=O)OC([2H])([2H])C([2H])([2H])[2H])C)C
InChI
InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+/i1D3,2D3,8D2,9D2
InChIKey
GKQPCPXONLDCMU-HBSDPXTRSA-N
Chemical Structure
2D Structure
2D structure of Lacidipine-d10
CAS: 1185245-62-8
CID: 45039638
Formula: C26H33NO6
MW: 465.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight465.6
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass465.29355523
Monoisotopic Mass465.29355523
Topological Polar Surface Area90.9 Ų
Heavy Atom Count33
Formal Charge0
Complexity805
Isotope Atom Count10
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-B0347-01Lacidipine
HY-B0347R-01Lacidipine (Standard)
HY-B0347S3Lacidipine-13C4
HY-B0347S1Lacidipine-13C8
HY-P0009S1Cetrorelix-d10
HY-13673SGoserelin-d10
HY-W744750TDHL-d10
HY-B1550SBenzoin-d10
HY-17371SOxaliplatin-d10
HY-126363SDitiocarb-d10

Alternative Products

CatalogName
MBS6043385-01Lacidipine-d10
CS-O-41011Lacidipine- D10
sc-220296Trans Lacidipine-d10
B1417-5.1Lacidipine

Popular Products