Minoxidil (hydrochloride)

• Description:

  Minoxidil (U10858) hydrochloride is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil hydrochloride is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

• Product Name Alternative:

  U10858 (hydrochloride)

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite; Potassium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Field of Research:

  Cardiovascular Disease

• Smiles:

  N=C1N=C (N2CCCCC2) C=C (N1O) N.Cl

• Molecular Formula:

  C9H16ClN5O

• Molecular Weight:

  245.71

• References & Citations:

  [1]Hadjipavlou-Litina D, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013 Jul;95 (7) :1437-49.|[2]Davies GC, et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol. 2005 Apr;124 (4) :686-94. |[3]Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984 Jan;82 (1) :90-3.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  69935-18-8