Minoxidil (hydrochloride)

• Description :

  Minoxidil (U10858) hydrochloride is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil hydrochloride is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

• CAS Number :

  [69935-18-8]

• Product Name Alternative :

  U10858 (hydrochloride)

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite; Potassium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Field of Research :

  Cardiovascular Disease

• Smiles :

  N=C1N=C(N2CCCCC2)C=C(N1O)N.Cl

• Molecular Formula :

  C9H16ClN5O

• Molecular Weight :

  245.71

• References & Citations :

  [1]Hadjipavlou-Litina D, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013 Jul;95 (7) :1437-49.|[2]Davies GC, et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol. 2005 Apr;124 (4) :686-94. |[3]Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984 Jan;82 (1) :90-3.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported