Minoxidil

Minoxidil

• CAS Number: 38304-91-5
• UNSPSC Description: Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].
• Target Antigen: Endogenous Metabolite; Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Minoxidil.html
• Purity: 99.99
• Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 7.14 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;warming;heat to 50°C)
• Smiles: NC1=NC(N2CCCCC2)=CC(N)=[N+]1[O-]
• Molecular Weight: 209.25
• References & Citations: [1]Hadjipavlou-Litina D, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013 Jul;95(7):1437-49. doi: 10.1016/j.biochi.2013.03.009. Epub 2013 Mar 28.|[2]Davies GC, et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol. 2005 Apr;124(4):686-94.|[3]Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984 Jan;82(1):90-3.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched