Minoxidil

• Description :

  Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

• Product Name Alternative :

  U10858

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Minoxidil.html

• Concentration :

  10mM

• Purity :

  99.99

• Solubility :

  DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 7.14 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 50°C)

• Smiles :

  NC1=NC(N2CCCCC2)=CC(N)=[N+]1[O-]

• Molecular Formula :

  C9H15N5O

• Molecular Weight :

  209.25

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Hadjipavlou-Litina D, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013 Jul;95 (7) :1437-49. doi: 10.1016/j.biochi.2013.03.009. Epub 2013 Mar 28.|[2]Davies GC, et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol. 2005 Apr;124 (4) :686-94.|[3]Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984 Jan;82 (1) :90-3.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [38304-91-5]