Granisetron-d6

• Description:

  Granisetron-d6 (BRL 43694-d6) is deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

• Product Name Alternative:

  BRL 43694-d6

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Neurological Disease; Cancer

• Smiles:

  O=C (C1=NN (C ([2H]) ([2H]) [2H]) C2=CC=CC=C12) N[C@H]3C[C@]4 ([H]) N (C ([2H]) ([2H]) [2H]) [C@] (CCC4) ([H]) C3

• Molecular Formula:

  C18H18D6N4O

• Molecular Weight:

  318.45

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Sanger GJ, Nelson DR. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron) . Eur J Pharmacol. 1989 Jan 10;159 (2) :113-24.|[3]Maleki-Dizaji N, Eteraf-Oskouei T, Fakhrjou A, The effects of 5HT3 receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation. Int Immunopharmacol. 2010 Sep;10 (9) :1010-6.|[4]Boccia RV, Gordan LN, Clark G, Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study. Support Care Cancer. 2011 Oct;19 (10) :1609-17.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1224925-80-7