Estrone 3-methyl ether

• Description:

  Estrone 3-methyl ether (Oestrone methyl ether; 3-O-Methylestrone) is a synthetic intermediate useful for synthesis of estrogen receptor modulator[1][2][3].

• Product Name Alternative:

  Oestrone methyl ether; 3-O-Methylestrone

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Drug Intermediate

• Related Pathways:

  Others

• Field of Research:

  Cancer

• Purity:

  98.82

• Solubility:

  DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OC)C=C4CC3

• Molecular Formula:

  C19H24O2

• Molecular Weight:

  284.39

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kuznetsov YV, et al. New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5 (10) -trienes: Synthesis, molecular modeling, and biological evaluation. Eur J Med Chem. 2018 Jan 1;143:670-682.|[2]Herman BE, et al. Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1. J Enzyme Inhib Med Chem. 2016;31 (sup3) :61-69.|[3]Kuznetsov YV, et al. New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5 (10) -trienes: Synthesis, molecular modeling, and biological evaluation. Eur J Med Chem. 2018 Jan 1;143:670-682.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1624-62-0]