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(Rac) -Roscovitine

CAT: 0804-HY-50892-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-50892-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Rac) -Roscovitine ((Rac) -Seliciclib) is a selective cyclin-dependent kinases (CDKs) inhibitor. (Rac) -Roscovitine binds to the active sites of CDKs competitively with ATP, inhibiting the phosphorylation activity of CDKs. (Rac) -Roscovitine induces apoptosis in cancer cells. (Rac) -Roscovitine is promising for research of cancers or other diseases associated with CDK dysregulation, such as neurodegenerative diseases, cardiac disorders, viral and protozoan infections, glomerulonephritis, and chronic inflammation[1].
CAS Number
186692-44-4
Product Name Alternative
(Rac) -Seliciclib; (Rac) -CYC202
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Apoptosis; CDK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Smiles
CCC(NC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1)CO
Molecular Formula
C19H26N6O
Molecular Weight
354.45
Precautions
P264-P280-P302+P352-P362+P364
References & Citations
[1]Jorda R, et al. Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity. J Med Chem. 2011 Apr 28;54 (8) :2980-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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