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Linifanib (Standard)

CAT: 0804-HY-50751RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-50751RSize:1 Each
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Description
Linifanib (Standard) is the analytical standard of Linifanib. This product is intended for research and analytical applications. Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis[1][2].
CAS Number
796967-16-3
UNSPSC
12352100
Target
Apoptosis; Autophagy; c-Fms; c-Kit; FLT3; PDGFR; Reference Standards; VEGFR
Related Pathways
Apoptosis; Autophagy; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F
Molecular Formula
C21H18FN5O
Molecular Weight
375.40
References & Citations
[1]Albert DH, et al. Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther, 2006, 5 (4), 995-1006.|[2]Monroig-Bosque PDC, et al. OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers. Sci Rep. 2018;8 (1) :13106. Published 2018 Aug 30.|[3]Banchi M, et al. Synergistic activity of linifanib and irinotecan increases the survival of mice bearing orthotopically implanted human anaplastic thyroid cancer. Am J Cancer Res. 2020;10 (7) :2120-2127. Published 2020 Jul 1.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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