PF-06282999 (Standard)

CAT: 0804-HY-19321R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19321R-01Size:5 mg
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Description
PF-06282999 (Standard) is the analytical standard of PF-06282999. This product is intended for research and analytical applications. PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.
CAS Number
[1435467-37-0]
UNSPSC
12352100
Target
Glutathione Peroxidase; Reference Standards
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(N)CN(C(C1=CC(Cl)=CC=C1OC)=C2)C(NC2=O)=S
Molecular Formula
C13H12ClN3O3S
Molecular Weight
325.77
References & Citations
[1]Dong JQ, et al. Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug Metab Dispos. 2016 Feb;44 (2) :209-19.|[2]Ruggeri RB, et al. Discovery of 2- (6- (5-Chloro-2-methoxyphenyl) -4-oxo-2-thioxo-3,4-dihydropyrimidin-1 (2H) -yl) acetamide (PF-06282999) : A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. J Med Chem. 20
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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M11851-01PF-06282999
A12517-25PF-06282999 25mg
A12517-50PF-06282999 50mg
A12517-100PF-06282999 100mg
A12517-1PF-06282999 1mg
A12517-5PF-06282999 5mg
A12517-200PF-06282999 200mg
A12517-10PF-06282999 10mg
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