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BVT 2733 (Standard)

CAT: 0804-HY-18054R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18054R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BVT 2733 (Standard) is the analytical standard of BVT 2733. This product is intended for research and analytical applications. BVT 2733 is a potent, selective, and orally active non-steroidal 11β-hydroxydehydrogenase 1 (11β-HSD1) inhibitor. BVT 2733 is potently against the mouse enzyme (IC50=96 nM) over the human enzyme (IC50=3341 nM) . BVT 2733 has the potential for the study of arthritis and obesity related disease[1].
CAS Number
376640-41-4
UNSPSC
12352100
Target
11β-HSD; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
ClC1=C(C)C(S(NC2=NC(CC(N3CCN(C)CC3)=O)=CS2)(=O)=O)=CC=C1
Molecular Formula
C17H21ClN4O3S2
Molecular Weight
428.96
References & Citations
[1]Zhang L, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17 (3) :489-94.|[2]Wang L, et al. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7 (7) :e40056.|[3]11β-hydroxydehydrogenase 1 (11β-HSD1) Inhibitor in Development
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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