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SCPI-1

CAT: 0804-HY-180460Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-180460Size:1 Each
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Description
SCPI-1 is a potent and competitive mosquito sterol carrier protein-2 (SCP-2) inhibitor (AeSCP-2 IC50 = 0.347 µM; AeSCP-x IC50 = 0.527 µM) . SCPI-1 exhibits physiological effects on cholesterol metabolism in cultured insect cells (IC50 = 5.53 µM in Aag-2 cells) . SCPI-1 shows insecticidal activity against Aedes aegypti with a LD50 of 4.8 µM[1].
CAS Number
339231-67-3
UNSPSC
12352005
Target
Others
Related Pathways
Others
Field of Research
Others
Smiles
O=C(C)NC1=CC=C(NC2=NC(C3=CC(Cl)=C(Cl)C=C3)=CS2)C=C1
Molecular Formula
C17H13Cl2N3OS
Molecular Weight
378.28
References & Citations
[1]Kim MS, et al. Identification of mosquito sterol carrier protein-2 inhibitors. J Lipid Res. 2005 Apr;46 (4) :650-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(4-((4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl)amino)phenyl)acetamide

a mosquito sterol carrier protein-2 inhibitor

CAS Number339231-67-3
PubChem CID1508365
IUPAC NameN-[4-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino]phenyl]acetamide
Molecular FormulaC17H13Cl2N3OS
Molecular Weight378.3
XLogP4.9
Topological Polar Surface Area82.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity434
SMILES
CC(=O)NC1=CC=C(C=C1)NC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl
InChI
InChI=1S/C17H13Cl2N3OS/c1-10(23)20-12-3-5-13(6-4-12)21-17-22-16(9-24-17)11-2-7-14(18)15(19)8-11/h2-9H,1H3,(H,20,23)(H,21,22)
InChIKey
XDFHOEGHGGFQKU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-((4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl)amino)phenyl)acetamide
CAS: 339231-67-3
CID: 1508365
Formula: C17H13Cl2N3OS
MW: 378.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.3
XLogP34.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass377.0156386
Monoisotopic Mass377.0156386
Topological Polar Surface Area82.3 Ų
Heavy Atom Count24
Formal Charge0
Complexity434
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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