Hepta-histidine

• Description:

  Hepta-histidine is an inhibitor of Ku70-Huntingtin protein interaction. Hepta-histidine can reverse the morphological abnormalities of primary neurons differentiatied from hiPSCs. Hepta-histidine prolongs the lifespan in severe Huntington’s disease R6/2 mouse model. Hepta-histidine ameliorates DNA damage in vitro. Hepta-histidine can be used to study anti-aggregation agent against Tau-associated neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease[1][2].

• UNSPSC:

  12352005

• Target:

  Huntingtin

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  [C@H](CC1=CN=CN1)(C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC4=CN=CN4)C(O)=O)=O)=O)=O)NC([C@H](CC5=CN=CN5)NC([C@H](CC6=CN=CN6)NC([C@H](CC7=CN=CN7)N)=O)=O)=O

• Molecular Formula:

  C42H51N21O8

• Molecular Weight:

  978.01

• References & Citations:

  [1]Kondo K, et al., Hepta-Histidine Inhibits Tau Aggregation. ACS Chem Neurosci. 2021 Aug 18;12 (16) :3015-3027.|[2]Imamura T, et al., Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016 Sep 22;6:33861.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound

• Clinical Information:

  No Development Reported

• CAS Number:

  [64134-31-2]