DAM-001

• Description :

  DAM-001 (Z236004662) is a potent, non-competitive allosteric inhibitor for human dopamine transporter (hDAT) with an IC50 of 24.70 μM and 1.026 μM in the absence and presence of orthosteric inhibitor Nomifensine (HY-B1110) [1].

• Product Name Alternative :

  Z236004662

• UNSPSC :

  12352005

• Target :

  Dopamine Transporter

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(C1CCCC1)N(CCC2)CC2C3=NC4=CC=CC=C4N3

• Molecular Formula :

  C18H23N3O

• Molecular Weight :

  297.39

• References & Citations :

  [1]Ye X, et al. Discovery of a new allosteric inhibitor for human dopamine transporter by physics-based modeling and experimental validation. Eur J Med Chem. 2026 Feb 5;303:118403.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1090396-31-8]