DAM-001

• Description:

  DAM-001 (Z236004662) is a potent, non-competitive allosteric inhibitor for human dopamine transporter (hDAT) with an IC50 of 24.70 μM and 1.026 μM in the absence and presence of orthosteric inhibitor Nomifensine (HY-B1110) [1].

• Product Name Alternative:

  Z236004662

• UNSPSC:

  12352005

• Target:

  Dopamine Transporter

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(C1CCCC1)N(CCC2)CC2C3=NC4=CC=CC=C4N3

• Molecular Formula:

  C18H23N3O

• Molecular Weight:

  297.39

• References & Citations:

  [1]Ye X, et al. Discovery of a new allosteric inhibitor for human dopamine transporter by physics-based modeling and experimental validation. Eur J Med Chem. 2026 Feb 5;303:118403.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1090396-31-8