NIK-IN-3

CAT: 0804-HY-179701Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179701Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NIK-IN-3 is a potent and orally active NF-κB-inducing kinase (NIK) inhibitor with an IC50 of 5.2 nM. NIK-IN-3 suppresses non-canonical NF-κB pathway activation and inhibits the secretion of pro-inflammatory cytokines, such as TNF-α, IL-6, IL-1β and chemokine CXCL12. NIK-IN-3 shows significant anti-inflammatory effects in LPS (HY-D1056) -induced sepsis mice model and DSS (HY-116282) -induced colitis model. NIK-IN-3 can be used for the research of inflammation, such as colitis[1].
UNSPSC
12352005
Target
CXCR; Interleukin Related; NF-κB; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O[C@](C1=NC=CS1)(C)C#CC2=CC=C(N3CCOCC3)C(NC4=CC=NC(NC5=NC=CCl=C5)=N4)=C2
Molecular Formula
C25H24ClN7O2S
Molecular Weight
522.02
References & Citations
[1]Zhang N, et al. Design, synthesis, and biological evaluation of novel NIK inhibitors for the treatment of inflammatory bowel disease and sepsis. Eur J Med Chem. 2026;302 (Pt 3) :118368.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; NF-κB

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